From the Manchester NH Airport:
When exiting the airport, take Route 3A North.
Take 101 West (Bedford/Nashua/Concord), and cross the Merrimack River.
When I-293 and the Everett Turnpike exit, stay on Route 101 West.
At the first light, follow Route 101 by taking a left.
At the next light, take a left into Constitution Drive.
Continue straight ahead to Independence Place.

From Concord:
I-93 South.
North of Manchester, take I-293 South.
Just south of Manchester, take Route 101 West.
At the first light, follow Route 101 by taking a left.
At the next light, take a left into Constitution Drive.
Continue straight ahead to Independence Place.

From Boston:
Take I-93 North to I-293/Route 101 West just south of Manchester.
Stay on Route 101 West to the first traffic light, and follow Route 101 by taking a left.
At the next light, take a left into Constitution Drive.
Continue straight ahead to Independence Place.

From Portsmouth:
Route 101 West to Manchester, and cross the Merrimack River.
At the first traffic light, stay on Route 101 by taking a left.
At the next light, take a left into Constitution Drive.
Continue straight ahead to Independence Place.